First Quarantine Legislation was introduced almost 644 years ago to the day __ July 27, 1377
The Adriatic port city of Ragusa (now Dubronvnik) passed the first legislation requiring the mandatory quarantine of all incoming ships and caravans. It required that all those coming from plague-infested areas had to spend 30 days in isolation on the islet of Mrkan or in the town of Cavtat, for the purpose of disinfection. This was during the time of the bubonic plague, or Black Death, which devastated Europe and Asia in the mid-1300s.
The Black Death was the most fatal pandemic in recorded human history, resulting in the deaths of between 75 and 200 million people.